산학연병 네트워크

분당차병원 연구중심병원 공동연구 신청 교수 게시판입니다.

이곳은 연구에 참여하는 교수진의 정보 제공을 통해 이용 고객 여러분의 편의를 제공하는 목적으로 개설되었습니다.
많은 분들의 관심과 이용을 부탁드립니다.

교수명 최민철
소속 분당차병원
진료과 부인암센터 (산부인과학교실)
분야 임상
연구분야 부인종양, 면역치료, 임상연구
Contact information oursk79@cha.ac.kr

세부정보

진료분야 산부인과 부인종양
연구분야 임상

연구개요

●As Principal Investigator
- Gonadotropin-releasing hormone (GnRH) agonist for prevention of chemotherapy induced menopause in malignant ovarian germ cell tumor: a multicenter prospective study (KGOG3048)
- Phase 2 Trial for Chemo-Resistant Gestational Trophoblastic neoplasias with Pembrolizumab (KGOG2024)
- Real-World Experience of Pembrolizumab Monotherapy in Patients with Recurrent or Persistent Cervical Cancer: A Korean Multi-Center Retrospective Study (KGOG1041)
- Post-Marketing Surveillance to confirm safety and efficacy of AKYNZEO capsule in Patients Receiving HEC or MEC


●As collaborator
- Evaluating rucaparib and nivolumab as maintenance treatment in newly diagnosed ovarian cancer patients (ATHENA/GOG-3020/ENGOT-ov45)
- A phase II study of Neoadjuvant chemotherapy plus Durvalumab (MEDI4736) and Tremelimumab in Advanced-stage ovarian cancer (KGOG3049)
- Phase II study of fertility-sparing management using high-dose oral progestin in young women with stage I endometrial adenocarcinoma with grade 2 differentiation or superficial myometrial invasion (KGOG2020)
- Phase II study of Belotecan monotherapy in patients with recurrent or persistent cervical cancer (KGOG1039)

대표 연구 업적

<<부인암 환자의 면역항암치료제 관련 연구>>
1. Effective anti-PD-1 treatment for chemo-resistant gestational trophoblastic neoplasia. European J of Cancer 2020
2. Real-World Experience of Pembrolizumab Monotherapy in Patients with Recurrent or Persistent Cervical Cancer: A Korean Multi-Center Retrospective Study (KGOG1041). Cancers 2020
3. Real-World Experience with Pembrolizumab Treatment in Patients with Heavily Treated Recurrent Gynecologic Malignancies. Yonsei Medical Journal
==>상기 연구업적을 통해 pembrolizumab을 이용한 Phase 2 Trial for Chemo-Resistant Gestational Trophoblastic neoplasias with Pembrolizumab (KGOG2024)을 진행중


<<부인암 환자의 가임력 보존 연구>>
1. Feasibility and efficacy of gonadotropin-releasing hormone agonists for the prevention of chemotherapy-induced ovarian insufficiency in patients with malignant ovarian germ cell tumours (KGOG 3048R). European J of Cancer
==>상기 연구 결과로 전향적 연구 Gonadotropin-releasing hormone (GnRH) agonist for prevention of chemotherapy induced menopause in malignant ovarian germ cell tumor: a multicenter prospective study (KGOG3048) 진행중

<<난소암 환자의 유전 분석>>
1. Clinical Impact of Somatic Variants in Homologous Recombination Repair-Related Genes in Ovarian High-Grade Serous Carcinoma. Cancer Research and Treatment
2. Serum exosomal miRNA-145 and miRNA-200c as promising biomarkers for preoperative diagnosis of ovarian carcinomas. Journal of Cancer
==> 상기 연구 결과로 특허 출헌


<<유전성 부인암 (유전성 난소/유방암 증후군, 린치 증후군)>>
1. Germline mutations of BRCA1 and BRCA2 in Korean ovarian cancer patients: Finding founder mutations.
2. Practice patterns of hereditary ovarian cancer management in Korea
3. Case Report of Menopausal Woman Diagnosed with Endometrial Cancer after Colon Cancer with Germline Mutation in MSH6 in Korea
4. Unclassified Variants of BRCA1 and BRCA2 in Korean Patients with Ovarian Cancer
5. Clinicopathologic characteristics of double primary endometrial and colorectal cancers in a single institution
6. Prevalence of germline BRCA mutations among women with carcinoma of the peritoneum or fallopian tube
7. Clinical significance of variants of unknown significances in BRCA genes


<<부인암 환자의 광역동치료>>
1. Fertility Preservation via Photodynamic Therapy in Young Patients With Early-Stage Uterine Endometrial Cancer A Long-term Follow-up Study.
2. Photodynamic Therapy for Management of Cervical Intraepithelial Neoplasia II and III in Young Patients and Obstetric Outcomes. )
3. Fertility Preservation by photodynamic therapy combined with conization in young patients with early stage cervical cancer: A Pilot Study
4. Fertility-sparing management combined with photodynamic therapy for endometrial stromal sarcoma: a case report
5. Photodynamic therapy for premalignant lesions of the vulva and vagina: A long-term follow-up study.

관심 연구 분야

한글 면역항암치료, 임상연구, 가임력 보존, 유전성 부인암, 광역동치료
영문 immuno-oncology, clinical trial, fertility sparing, hereditary gynecologic cancer, photodynamic therapy

공동 연구 희망 주제

● 부인암 환자의 (병합)면역항암치료

● 유전성 부인암 환자 (BRCA관련 난소암 증후군, 린치 증후군) 의 관리 및 치료

● 부인암 환자의 가임력 보존 연구